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"Metabolomics in Multiomics Research: 5 Key Case Studies of Multiomics Research Driving Novel Insight Discovery"

Multiomics research is crucial for understanding complex biological systems at a comprehensive level. By integrating data from genomics, transcriptomics, proteomics, metabolomics, and other omics disciplines, researchers can unravel intricate interactions and pathways within cells and organisms.

By helping researchers to more easily integrate multiomics data, multiomics studies can accelerate the path to novel actionable insights, identifying biomarkers and pathway associations that show the relationships and causalities of genetics, environment, and lifestyle on biological systems.

In this webinar, Brian Keppler, Ph.D., Director of Discovery and Translational Sciences at Metabolon, explores five publications that highlight the utility of multiomics research. These publications span different omic technologies and research applications which demonstrates the importance of multiomic insights.

About Metabolomics

Metabolomics, the study of small molecules, is integral to multiomics research. Analyzing metabolites complements genomics, proteomics, and transcriptomics, providing a snapshot of cellular function and metabolic changes. Combining metabolomics with other omics data enhances understanding of biological systems and adds additional insights into the phenotype.

You will learn:

• How metabolomic data can be combined with genomics, proteomic, and microbiome analysis to produce novel insights into disease
• Considerations for designing multiomic studies
• Benefits of targeted and untargeted metabolomics approaches

Presenter

Title/Abstract

Brian Keppler, Ph.D.

This section of the webinar discusses how metabolomics can provide insights that connect information across the central dogma of molecular biology. Dr. Keppler then discusses 3 of the 5 case studies presented in this webinar, outlined below:

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Multi-omics data integration reveals metabolome as the top predictor of the cervicovaginal microenvironment

Multi-omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients

Heino Heyman, Ph.D.

Achieving fast, accurate, and reproducible metabolomic data can be a challenging task that requires investing in people, technology, and novel methods to derive functional insights. In this short session, we demonstrate how Metabolon’s metabolomics-as-a-service solution can be leveraged to improve metabolite-level insights today.

Brian Keppler, Ph.D.

Dr. Keppler continues his presentation with the final 2 case studies:

Multiomics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes

Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers

Brian Keppler, Ph.D. & Heino Heyman, Ph.D.

Questions & Answers

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