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"Exploratory Toxicology for Neuroscience Drug Discovery"

Predictive Data to Support Confidence in Neuroscience Drug Discovery

Gathering early insight into the distribution, off-target effects, and potential toxicity of your lead small molecule is vital to avoid costly waste of time and resources and future setbacks. This eBook describes strategies across the early stages of drug discovery to support confidence in your lead small molecule candidate and to ensure you proceed through the drug development process with the most promising candidate.

eBook contents include:

• Screening and cell-based assays
  • Assessing neurotoxicity in advanced cell models
  • hERG toxicity screening
  • Assessing cardiotoxicity with multi-electrode array electrophysiology
  • Retrogenix® cell microarray for off-target screening
• Bridging in vitro and in vivo
  • Determine brain penetration with microdialysis
  • Visualize distribution and target engagement in vivo
• In vivo toxicology
  • Off-target effects via neurotransmitter analysis
  • GLP neurotoxicity services

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