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"Transferring your cell line with confidence"

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Mammalian expression systems, particularly Chinese Hamster Ovary (CHO) cells, are the gold standard for producing recombinant therapeutic proteins and the dominant platform in commercial manufacturing. Advances in science and technology have led to the development of CHO cell variants with improved productivity, stability, product quality, and safety. Given the diverse nature of these cell lines, optimizing process conditions is essential to maximize cell growth and maintain product quality. Other factors like molecule complexity, development site capabilities, and expertise also influence the success of this critical bioprocessing step. To address these challenges, Lonza has leveraged its technical and regulatory expertise to develop proven strategies that enable efficient, reproducible production across diverse molecule types and expression technologies. This white paper explores case studies that offer insights into the strategies that drive high-quality biologics manufacturing.

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